1834, American English, fanciful mock-Latin coinage of a type popular then (originally discombobricate). Compare, on a similar pattern, confusticate (1852), absquatulate (1840), spifflicate “confound, beat” (1850), scrumplicate “eat” (1890). Related: discombobulating; discombobulation.
I say we need to bring back spifflicate and scrumplicate. Especially scrumplicate. It sounds like the process of taking a bland dish and making it complicated but delicious. Like twice-baked potatoes are so scrumplicated.